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NAFLD and Dementia

By Tucson Functional Medicine on November 14, 2022 0 Comments

A study from the journal Neurology revealed that nonalcoholic fatty liver disease (NAFLD) is independently associated with cognitive impairment.

Nonalcoholic fatty liver disease (NAFLD) is an umbrella term for various liver conditions affecting people who drink little to no alcohol. As the name implies, the main characteristic of NAFLD is too much fat stored in liver cells.

Dementia and NAFLD are two frequent conditions that share underlying risk factors, mainly in metabolic disease. 

The study from the journal, Neurology included 4,472 adults aged 20–59 years.

The participants underwent an assessment of liver enzyme activity and hepatic steatosis by ultrasound. In addition, they underwent cognitive evaluation using the following computer-administered tests: the Simple Reaction Time Test (SRTT), the Symbol-Digit Substitution Test (SDST), and the Serial Digit Learning Test (SDLT).

 

Increased activity of the liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) correlated with lower performance on the SDLT. In comparison, increased alanine aminotransferase was also associated with lower performance in the SDST.

The current studies suggest that NAFLD patients incur cognitive dysfunction.

Although if left untreated, NAFLD can lead to much more severe conditions, including cirrhosis and liver failure. The good news is that fatty liver disease can be reversed—and even cured.

8 Steps to Effectively Treat Fatty Liver Disease

1. Lose excess weight–losing between 7 and 10 percent of body weight can improve other symptoms of NAFLD, such as inflammation, fibrosis, and scarring

2: Research from 2017 suggests that the Mediterranean diet may help to reduce liver fat, even without weight loss.

3: Exercise: It’s essential to stay active when you have NAFLD. A good goal is at least 150 minutes of moderate-intensity exercise per week.

4: Avoid foods with added sugars-Dietary sugars such as fructose and sucrose have been linked to the development of NAFLD.

5: Take an omega-3 supplement–A peer-review study suggests that taking an omega-3 supplement may reduce liver fat.

6: Avoid known liver irritants: Certain substances can stress your liver excessively. They include alcohol and confident over-the-counter medications.

7: Consider taking vitamin E--Vitamin E is one antioxidant that may reduce inflammation caused by NAFLD. Must take all components of vitamin E. This would include Mixed Tocopherols and Tocotrienols

8: Consider Herbs--A 2018 paper identified herbs, supplements, and spices used as alternative treatments for NAFLD. Compounds shown to affect liver health positively include turmeric, milk thistle, resveratrol, and green tea.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820136/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400092/

NAFLD and Dementia

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.22752

https://www.hindawi.com/journals/grp/2016/1459790/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789322/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165515/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960814/

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